Some selected major PK/PD publications

Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective

Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective.

Mouton JW, Ambrose PG, Canton R, Drusano GL, Harbarth S, MacGowan A, Theuretzbacher U, Turnidge J.
Drug Resist Updat. 2011 Apr;14(2):107-17

The effect of critical illness on drug distribution

The effect of critical illness on drug distribution.

Gonzalez D, Conrado DJ, Theuretzbacher U, Derendorf H.
Curr Pharm Biotechnol. 2011 Dec;12(12):2030-6.

Protein binding: do we ever learn?

Zeitlinger MA, Derendorf H, Mouton JW, Cars O, Craig WA, Andes D, Theuretzbacher U.
Antimicrob Agents Chemother. 2011 Jul;55(7):3067-74.

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization.

Nielsen EI, Cars O, Friberg LE.
Antimicrob Agents Chemother. 2011 Oct;55(10):4619-30

In vitro pharmacodynamic models to determine the effect of antibacterial drugs

In vitro pharmacodynamic models to determine the effect of antibacterial drugs.

Gloede J, Scheerans C, Derendorf H, Kloft C.
J Antimicrob Chemother. 2010 Feb;65(2):186-201.

Significance of protein binding in pharmacokinetics and pharmacodynamics

Significance of protein binding in pharmacokinetics and pharmacodynamics.

Schmidt S, Gonzalez D, Derendorf H.
J Pharm Sci. 2010 Mar;99(3):1107-22.

A long journey from minimum inhibitory concentration testing to clinically predictive breakpoints: deterministic and probabilistic approaches in deriving breakpoints.

Dalhoff A, Ambrose PG, Mouton JW.
Infection. 2009 Aug;37(4):296-305.

Back to the future: using aminoglycosides again and how to dose them optimally.

Drusano GL, Ambrose PG, Bhavnani SM, Bertino JS, Nafziger AN, Louie A.
Clin Infect Dis. 2007 Sep 15;45(6):753-60

Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it's not just for mice anymore.

Ambrose PG, Bhavnani SM, Rubino CM, Louie A, Gumbo T, Forrest A, Drusano GL.
Clin Infect Dis. 2007 Jan 1;44(1):79-86.

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
Johan W. Mouton, Michael N. Dudley, Otto Cars, Hartmut Derendorf and George L. Drusano
Journal of Antimcrobial Chemotherapy (2005) 55: 601-607

Please login to read complete article