hdr isap 2019

News November 2013

The European Medicines Agency (EMA) recently released an Addendum to the guideline on the evaluation of medicinal products indicated for the treatment of bacterial infections. One of the most important aspects of the addendum is that it outlines a new approach facilitating the development of antibacterial agents targeted against multidrug-resistant pathogens where patients have very limited or no remaining treatment options. Accepting limited evidence of clinical safety and efficacy is strongly based on extensive preclinical and clinical PK/PD analyses. PK/PD studies may play a pivotal role in alternative study designs in indications where placebo controls are required as well as in limited pre-licensure clinical development programmes targeting multidrug-resistant pathogens.The field of PK/PD will be an essential pilar in the development of novel antibacterial drugs to treat infections due to multidrugresistant organisms that are currently uncommon or rare and for which there are few remaining therapeutic options.

News June 2013

The ISAP organizing committee invites young investigators to submit their abstracts (in ICAAC format) for oral presentation during the ISAP meeting. To ensure the work of different research groups are well represented, please limit one abstract submission per senior (corresponding) investigator.  The abstracts will be evaluated by a panel of independent senior scientists, based on relevance to PK/PD and scientific merits.  Please submit your abstract by email to Dr. Brian Tsuji ( This email address is being protected from spambots. You need JavaScript enabled to view it.) by July 15, 2013. Abstracts selected for presentation will be notified by August 23, 2013.

The annual meeting and post-ICAAC symposium will take place on September 13th, 2013, 2:00-6:00 PM in Denver, Collorado, USA

News February 2013

1st International Workshop on Clinical Pharmacology of Antifungal Drugs and Fungal Diseases, to be held on 26 April 2013 in Berlin, Germany, preceding the ECCMID 2013. This one-day international abstract-driven scientific and educational workshop will consist of invited lectures, oral abstract and clinical case presentations and a poster viewing session. Read more here...

News May 2013

The 1st International Conference on Polymyxins, an opinion-leader conference to present and learn of the latest findings on the polymyxin antibiotics, took place in on 2 - 4 May, 2013 at the Monash University Centre in Prato, Italy. The organizers and most members of the organizing committee are active members of ISAP: Roger Nation, Australia (Chair), Jian Li, Australia (Deputy Chair), Otto Cars, Sweden, William Couet, France, Mike Dudley, USA, Bob Hancock, Canada, Johan Mouton, Netherlands, David Paterson, Australia, Vincent Tam, USA, Ursula Theuretzbacher, Austria, Brian Tsuji, USA, John Turnidge, Australia.

Despite worldwide fast growth of basic and clinically applied knowledge several key issues such as the optimal dosing regimen (loading dose, timing of first maintenance dose and maintenance doses), potential clinic advantage of combination vs monotherapy, management strategies of nephrotoxicity, huge variability of drug exposure, role for therapeutic drug monitoring, wide quality specifications of content, confusing labelling in different countries, in vitro testing challenges, remain. Shortly, the presentations of the Polymyxin Conference will be posted on the ISAP website. Within each symposium key issues have been identified that will be summarised in the Prato Polymyxin Consensus, in which recommendations will be published to guide the clinical use of polymyxins and identify high-priority areas for further research.

Supporters of the Polymyxin Conference: ISAP, The EU funded project AIDA (Preserving old antibiotics for the future), PK/PD Study Group of ESCMID, ESCMID

News January 2013

It is our pleasure to invite you to join 7th International Symposium on Microdialysis which will be held in Poitiers from 23 to 24 May 2013. William Couet and colleagues organized an ambitious program.
Multiple aspects of microdialysis will be covered from basic research to patient monitoring with focus on the latest developments. Leaders in the field will come from around the world to present their most recent data but numerous oral sessions will be reserved for short oral presentations by young investigators.
Registrants are invited to submit abstracts for consideration of presentation as posters. The closing date for submission of abstracts is 1st March 2013.