hdr isap 2019

News May 2014

ISAP publication - Bedside dosing!
Lancet Infect Dis April 2014

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

Jason A Roberts, Mohd H Abdul-Aziz, Jeff rey Lipman, Johan W Mouton, Alexander A Vinks, Timothy W Felton, William W Hope, Andras Farkas, Michael N Neely, Jerome J Schentag, George Drusano, Otto R Frey, Ursula Theuretzbacher, Joseph L Kuti, on behalf of The International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases

ISAP and EPASG recently published this review on individualised dosing for critically ill patients. In this review, we explore the challenges related to patients and pathogens that contribute to inadequate antibiotic dosing and discuss how to implement a process for individualised antibiotic therapy that increases the accuracy of dosing and optimises care for critically ill patients.

Please sign in and read the full paper.

News April 2014

Opportunity for Young Investigator!

The Department of Clinical Pharmacology, one of the largest departments in Europe in its field and dedicated to clinical research, is seeking a young expert in PK and/or PK/PD modelling for building a Vienna modelling research group.

Antimicrobial agents will be one major focus of this group within the department; however, Vienna Research Group leaders are to be independent in designing their research work and recruiting their staff. WWTF (funding organisation for research projects of the city of Vienna) in total grants up to 1.6 Mio. € per research group for six to eight years. Full proposal have to be submitted by 24 July 2014 by the research institution.

More information can be found here or by contacting Markus Zeitlinger (markus zeitlinger(at)meduniwien.ac.at)

News January 2014

A high chocolate consumption has been linked with increased body weight but also with reduced risks for the development of cardiometabolic disorders.
This study contributes important new insights into the chocolate consumption in a hospital ward environment and the half lives of two brands of chocolates. Continue reading this study and remember the results any time you contribute to the short survival time of chocolates on hospital wards or labs.

News December 2013

Tissue concentrations again (Eng`s principle of medical procedures: „The easier it is to do, the harder it is to change.“)
Stein et al recently published a paper in the Journal of Antimicrobial Chemotherapy reporting the tissue penetration of trimethoprim/sulfamethoxazole and linezolid in patients with diabetic foot infection to support their use in the treatment of diabetic foot infections (JAC 2013; 68: 2852–2858). This study used tissue biopsy homogenates to determine the concentrations at the site of infection, a method that measures a mixture of total (bound+free) concentrations in intra-, extracellular and blood compartments where antibiotics and bacteria are not distributed evenly. It is difficult to discourage methods that are easy and cheap though they bring potenially misleading results.
ISAP and the ESCMID PK/PD study group submitted a response to JAC with the intention to raise awareness regarding methodological pitfalls of tissue concentration measurements.