News March 2022

Dear ISAP members!

As the situation in Europe is steadily stabilizing after the pandemic winter, we are pleased to share with you information on two upcoming events around the ECCMID meeting in April 2022:

EPASG Pre-ECCMID Course
Prior to ECCMID, on 21-22 April 2022, EPASG is hosting a on-site workshop titled "Optimised dosing of antibiotics - understanding PK/PD, clinical breakpoints, and therapeutic drug monitoring" in Oerias (close to Lisbon), Portugal. ESCMID indicated that the course is filling up quickly. The program can be found here. Register here, if you are interested to join!

ISAP Meeting
Right after the EPASG course on 22 April 2022, and hence on the evening before ECCMID, we will hold an ISAP Scientific Meeting from 16.30 to approx. 20.00 in the same hotel (Lagoas Park, Oerias) as the EPASG course, in Oerias, Portugal. Registration is now closed.

Location (ca. 20 mins from Lisbon airport/Lisbon city centre by taxi):
Lagoas Park Hotel
Rua Encosta das Lagoas
2740-245 Porto Salvo, Portugal

Program:

16.15-16.30 Arrival and Welcome
16.30-17.15 ISAP General Meeting
17.15-19.00 Young Investigator Session

First name	Last Name	Title
Aneeq	Farooq	Interaction screening of ceftazidime-avibactam and tigecycline against six clinical and nine isogenic E. coli and K. pneumoniae strains expressing carbapenemases
Wisse	Van Os	Impact of individual ascitic fluids on bacterial growth and ceftriaxone effect in an in vitro model of spontaneous bacterial peritonitis
Nicole	Zimmermann	Integrated in vitro approach to understand the exposure-effect relationship of fosfomycin against Escherichia coli
Amaury	O'Jeanson	A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against β-lactamase-producing Gram-negative bacteria
Jinxin	Zhao	PhageGE: An Interactive Web-based R Shiny Application for Bacteriophage Pharmacology
Sue	Nang	Elucidating the pharmacokinetics/ pharmacodynamics of bacteriophage therapy against Pseudomonas aeruginosa using a mouse bacteraemia model
Romain	Aubry	Semi-mechanistic PKPD modelling of ceftazidime/avibactam and colistin combination against five multidrug resistant Klebsiella pneumoniae isolates
Mathilde	Lacroix	In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin
Matthias	Gijsen	Model-based TDM of vancomycin: a retrospective comparison with routine TDM-based dosing
Gert-Jan	Wijnant	Pharmacokinetics and PK/PD of temocillin in non-ICU urinary tract infection patients with various stages of renal insufficiency
Tim	Ewoldt	Large variability of unbound active fraction of ceftriaxone in contrast to ciprofloxacin in plasma of critically ill patients
Maria	Sanz Codina	Relationship between pharmacokinetic/pharmacodynamic target attainment and microbiological outcome in critically ill COVID-19 patients with documented Gram-negative superinfections treated with meropenem continuous infusion

19.00-20.00 Reception with light food and beverages

We hope to see you in Portugal, soon!

Best regards

ISAP Council

News September 2021

ISAP-EPASG Meeting November 12-13 2021

Dear ISAP members,

We are pleased to share the first circular of our program for the upcoming ISAP-EPASG Meeting on November 12-13 2021. The meeting will start at 1.00 PM CET on November 12 and finish at 14.15PM on November 13. Please find the current version of the program here.

Call for abstracts for the Young Investigator Session
As per ISAP tradition, also the upcoming meeting will contain a Young Investigator Session, which is organised by Alina Nussbaumer-Pröll (Vienna, Austria) and Elisabet Nielsen (Uppsala, Sweden). We encourage all Young Investigators to actively contribute by submitting abstracts for a 5–10-minute oral talk (depending on the number of participants) about your current data or project followed by 2–5-minutes questions and answers. You are also welcomed to present data that has been already approved at ECCMID 2021. To submit abstracts, we would ask you to send an e-mail with your abstract (in any format) to This email address is being protected from spambots. You need JavaScript enabled to view it. until the 10th of October. Abstracts will be reviewed by the scientific committee. Please include your affiliation and full name.

Best regards,

ISAP Council

News March 2021

ISAP-EPASG Webinar

On Tuesday, March 9 2021 at 12.30PM CET, Dr Shampa Das, Liverpool, UK will deliver a webinar on the topic "Considerations in the use of PK-PD and probability of target attainment analysis in breakpoint setting."

The webinar is free for ISAP members and the dial-in information will be send to ISAP members via the newsletter.

News April 2021

Virtual ISAP Meeting May 2021

After our first successful virtual meeting in February, we would like to invite you to our 2nd virtual ISAP meeting:

The meeting will take place in the US/European time zone on May 26 2021 4PM - 6PM CEST and will be held online.

The meeting will start with a keynote presentation by Dr. Sujata Bhavnani (NY, USA) with a presentation titled:

"Antimicrobial Therapy: Precision Medicine and Beyond"

After the keynote, five Young Investigators from all around the globe will share their research:

Presenter	Title
Sue Nang	Polymyxins: 'Pseudo'-resistance in Klebsiella pneumoniae
Johanna Seeger	Quantification of persister formation of Escherichia coli lerveraging electronic cell counting and semi-mechanistic pharmacokinetic/pharmacodynamic modelling
Lisa Amann	Continuous infusion of tigecycline as an improved treatment option? Insights from a hollow fiber study
Karol Sokolowski	Evaluating Glutathione-conjugated Hydrogels as Localized Antibiotic Delivery Vehicles for Treatment of Bacterial Infections
David Busse	Probability of target attainment of antibiotics in obese patients: Do conventional pharmacokinetic/pharmacodynamic targets adequately capture target-site penetration?"

Dial-in information are shared via the Newsletter - check your inbox!

News January 2021

Virtual US/Australian Virtual ISAP Scientific Meeting

As discussed in our Annual Meeting in the fall, we wanted to initiate a ‘time-zone optimized’ virtual meeting series to foster scientific exchange and give our Young Investigators the opportunity to present their research. We are happy to announce that we will start this series in the US/Australian time zone on February 2 2021 5 PM (Orlando time) / February 3 2021 9 AM (Melbourne time).
The meeting will start with a keynote presentation, delivered by two excellent speakers from our community:
Dr. Cornelia Landersdorfer (Monash University, Australia) and Dr. Jürgen Bulitta (University of Florida, USA) will deliver a presentation entitled

‘Novel approaches to leverage molecules assays and disease-specific pharmacokinetics for translational antimicrobial pharmacology’.

After the keynote, there will be opportunities for Young Investigators to present their research.

The following Young Investigators will present their research:

Presenter	Title
Xingchen Bian	Is withdrawal of polymyxin breakpoints by CLSI justified: A Chinese perspective on intravenous polymyxin B for the treatment of bloodstream infection caused by multidrug-resistant Gram-negative pathogens.
Akosua Adom Agyeman	Evaluation of meropenem and tobramycin combination dosage regimens against hypermutable Pseudomonas aeruginosa strains via the dynamic hollow fibre infection model and mechanism-based modelling.
Nitin Patil	The Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Yang Hu	Perturbations of gut microbiome in mice by polymyxin treatments
Yinzhi Lang	Novel cassette assays to quantify the outer membrane permeability of β-lactams in carbapenem-resistant Gram-negative bacteria
Alaa Sayed	Inhibitory Binding Profiles for β-lactams and Penicillin-Binding Proteins in Mycobacterium abscessus
Jieqiang Zhou	Thermal stability of β-lactam antibiotics in broth, agar and water: Precisely achieving target concentrations in vitro by supplement dosing algorithm that offset thermal degradation
Yan Zhu	Unculturable Acinetobacter baumannii escapes from polymyxin killing via dependent

Dial-in information have been sent via the newsletter!