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Training

11 - 12 April 2019

Amsterdam, The Netherlands
Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

3 - 4 June 2016

Tübingen, Germany

Individualized Medicine in Infectious Diseases: a Practical Approach

13 - 16 April 2016

Lyon, France

Population Modeling and Dose Optimization with Pmetrics and BestDose: Antimicrobial Applications

19 - 21 November 2015

Warsaw, Poland
Improving the Dosage of Old Antibiotics

5 - 6 November 2015

Ferney-Voltaire, France
Moving Antimicrobial Stewardship Forward in Special Population Settings

2 - 3 October 2014

Annecy, France
Postgraduate Education Course Infection Management in the Elderly: A Wide Room for Improvement

6 - 8 October 2014

Liverpool, United Kingdom
Postgraduate Technical Workshop Advanced Antimicrobial Pharmacokinetic and Pharmacodynamic Modelling and Simulation

16 - 18 September 2014

Linz, Austria
Postgraduate Technical Workshop 3rd Workshop on Antimicrobial Susceptibility Testing and Surveillance

4 - 6 July 2014

Nijmegen, The Netherlands

Bringing PK and PD in Fungal Infections into the Clinic
PEC-antifungal-PKPD-1wCourse Coordinators
• Roger Brüggemann, Nijmegen, The Netherlands
• Joseph Meletiadis, Athens, Greece
• Ursula Theuretzbacher, Vienna, Austria
• Andrew J. Ullmann, Würzburg, Germany

Course Objectives
• To learn PK/PD principles of antifungal therapy
• To learn the pharmacokinetic differences among different patient populations
• To understand resistance mechanisms of fungi and their impact on antifungal treatment
• To learn how to use in vitro susceptibility data and to understand what breakpoints mean
• To explore the utility of therapeutic drug monitoring, the principles of dose adjustment, and how to optimize the therapy
• To understand the different clinical approaches of antifungal therapy and prophylaxis
• To learn how to apply antifungal stewardship in your centre

Faculty Members

Roger Brüggemann, Nijmegen, The Netherlands              Joseph Meletiadis, Athens, Greece
Werner Heinz, Würzburg, Germany Johan Mouton, Nijmegen, The Netherlands
William Hope, Liverpool, United Kingdom Livio Pagano, Rome, Italy
Christine Imbert, Poitiers, France Maurizio Sanguinetti, Rome, Italy
Evelyne Jacqz-Agrain, Paris, France Ursula Theuretzbacher, Vienna, Austria
Johan Maertens, Leuven, Belgium Andrew J. Ullmann, Würzburg, Germany
Oscar Marchetti, Lausanne, Switzerland Paul Verweij, Nijmegen, The Netherlands

Oct 8-11, 2012

Athens, Greece

The ESCMID PK/PD Study Group organized a 4-day technical workshop in Athens, Greece, Oct 8-11, 2012
A Statistical Approach to PK/PD Analysis in Practice
EPASG-course-2012-1w
Course Coordinators
•     Eleftheria Mavridou, Nijmegen, NL
•     Joseph Meletiadis, Athens, GR
•     Johan W. Mouton, Nijmegen, NL
Course Objectives
•     Provide guidance on how to implement adequate statistical analysis to evaluate the pharmacokinetic and pharmacodynamic data
•     Understand PK/PD indices, principles of CART analysis and how to apply these to establish
clinical breakpoints
•     Learn how to perform univariate and multivariate analysis, linear and nonlinear regression
analysis, including the ins and outs of the Emax model
•     To clarify the principles of pharmacokinetic parameters (peak and trough levels, volume of
distribution, area under the concentration curve) and the factors that affect them
•     Explain how to perform compartmental and non-compartmental pharmacokinetic analysis
•     Understand how to measure and analyse drug combination effects and how to determine
synergy and antagonism, including the Greco and Bliss models    
•     Perform analysis with different software programs
Faculty Members
•     Saiden Abbas, Nijmegen, NL
•     Roger Brüggemann, Nijmegen, NL
•     William Hope, Manchester, UK
•     Pavol Jancura, Nijmegen, NL
•     Klaus Skovbo Jensen, Copenhagen, DK
•     Eleftheria Mavridou, Nijmegen, NL
•     Joseph Meletiadis, Athens, GR
•     Johan W. Mouton, Nijmegen, NL
•     Anouk E. Muller, Rotterdam, NL
•     Ursula Theuretzbacher, Vienna, AT

Workshops

2019 - ASM MICROBE WORKSHOP

| Ursula Theuretzbacher | Activities - Workshops

ASM microbe Workshop 2019

Thursday, June 20 2019 at Mocscone Center, San Francisco, CA, USA, 12:30PM - 4:00PM

Introduction to Pharmacokinetics/Pharmacodynamics: a Basic Primer

Workshop Moderator
Brian Tsuji; Univ. at Buffalo, Buffalo, NY
Workshop Moderator
Roger Nation; Monash Univ., Parkville, AL, Australia
PK-PD Relationships of Antimicrobials: An introduction
Brian Tsuji; Univ. at Buffalo, Buffalo, NY
Concepts in Antimicrobial PK-PD: Linking to Humans
Elizabeth Lakota; Inst. for Clinical Pharmacodynamics, Inc., Schenectady, NY
Use of In-vitro Models to Elucidate the PK-PD Driver of Antimicrobial Activity
Roger Nation; Monash Univ., Parkville, AL, Australia
Animal Models and Their Use in Defining PK-PD Relationships
Vincent Tam; Univ. of Houston, Houston, TX

2018 - ISID WORKSHOP

| Gert Brouwer - webmaster | Activities - Workshops

ISID Workshop 2018

18th Congress of the International Society for Infectious Diseases
Saturday, March 3 2018 at Sheraton Buenos Aires Hotel & Convention Center, Buenos Aires, Argentina, 5:00PM - 6:00PM

Workshop session titled "Optimized Antibiotic Use"

Individualized Antibiotics Use - an Introduction
Ursula Theuretzbacher; CEFAIA, Vienna, Austria
Bring your tablet – Individualized Antibiotic Dosing with Interactive Case Studies
Sebastian Wicha; University of Hamburg, Hamburg, Germany

2015 - ICAAC WORKSHOPS

| Gert Brouwer - webmaster | Activities - Workshops

ICAAC Workshops 2015

Thursday, September 17 at San Diego Convention Center, CA, USA, 8:30AM - 4:30PM

 Workshop.55-01.Introduction to Pharmacokinetics/Pharmacodynamics 

Workshop Convener
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Workshop Convener
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Introduction to Pharmacokinetics
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Introduction to Pharmacodynamics
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Linking Pharmacokinetics and Pharmacodynamics
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Introduction to In vitro Infection Models
Roger L. Nation, PhD - Professor
Monash Univ., Melbourne, Australia.
Introduction to In vivo Infection Models
Vincent H. Tam, PharmD - Professor
Univ. of Houston Coll. of Pharmacy, Houston, TX.

2014 - ICAAC WORKSHOPS

| Gert Brouwer - webmaster | Activities - Workshops

ICAAC Workshops 2014

Friday Sept. 5. 2014 at the Walter E. Washington Convention Center, Washington DC, USA, 8:30AM - 4:30PM

 Workshop.54-01.Introduction to Pharmacokinetics/Pharmacodynamics 

Workshop Convener
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Workshop Convener
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Introduction to Pharmacokinetics
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Introduction to Pharmacodynamics
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Linking Pharmacokinetics and Pharmacodynamics
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Introduction to In vitro Infection Models
Roger L. Nation, PhD - Professor
Monash Univ., Melbourne, Australia.
Introduction to In vivo Infection Models
William A. Craig, MD - Emeritus Professor
Univ. of Wisconsin, Madison, WI.

Workshop.54-03.Application of Pharmacokinetic/Pharmacodynamic Models

Workshop Convener
Sujata M. Bhavnani, PharmD, MS - Vice President
ICPD, Latham, NY.
Workshop Convener
Alan Forrest, Pharm D - Research Professor and Senior Director of Pharmacometrics
Univ. at Buffalo and Inst. of Clin. Pharmacodynamics, Buffalo, NY.
Use of Population Pharmacokinetic Modeling in Therapeutic Drug Monitoring
Alexander A. Vinks, PharmD, PhD - Professor
Univ. of Cincinnati, Cincinnati, OH.
Monte Carlo Simulation: Application to Dose Selection and Identification of Susceptibility Breakpoints
Sujata M. Bhavnani, Pharm.D., M.S. - Vice President
ICPD, Latham, NY.
Modeling and Prediction of Anti-Infective Activity
Alan Forrest, Pharm D - Research Professor and Senior Director of Pharmacometrics
Univ. at Buffalo and Inst. of Clin. Pharmacodynamics, Buffalo, NY.
Resistant Breakpoint Determination
Alasdair MacGowan, MD - Professor
North Bristol NHS Trust & Univ. of Bristol, Bristol, United Kingdom.
Pharmacokinetics/Pharmacodynamics to Characterize and Overcome Resistance
George Drusano, MD - Professor and Director
Univ. of Florida, Orlando, FL.

Workshop.54-02.Clinical Pharmacokinetics/Pharmacodynamics

Workshop Convener
Vincent H. Tam, PharmD - Professor
Univ. of Houston Coll. of Pharmacy, Houston, TX.
Workshop Convener
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Clinical Application of Pharmacokinetics and Pharmacodynamics
Vincent H. Tam, PharmD - Professor
Univ. of Houston Coll. of Pharmacy, Houston, TX.
Combination Therapy
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Clinical Considerations of Obesity
Manjunath Pai 
Albany Coll. of Pharmacy and Hlth. Sci., Albany, NY
Dosing in Special Patient Populations
Markus Zeitlinger, MD - Associate Professor
Med. Univ. Vienna, Vienna, Austria.
Individualized Dosing and Therapeutic Drug Monitoring
Thomas P. Lodise JR
Albany Coll. of Pharmacy and Hlth. Sci., Albany, NY..

 Workshop.54-04.Pharmacokinetic/Pharmacodynamic Modeling of Anti-Infective Agents

Workshop Convener
David R. Andes, MD - Professor
Univ. of Wisconsin, Madison, WI.
Workshop Convener
George Drusano, MD - Professor and Director
Univ. of Florida, Gainesville, FL.
 In Vitro Dynamic Models for Antibiotic Pharmacokinetics-Pharmacodynamics
Warren E. Rose
Univ. of Wisconsin, Madison, WI
Hollow Fiber System
George Drusano, MD - Professor and Director
Univ. of Florida, Gainesville, FL
Animal Models for Pharmacokinetics/Pharmacodynamics
David R. Andes, MD - Professor
Univ. of Wisconsin-Madison, Madison, WI
A Pharmacometric-Based Approach to Facilitate Critically Needed Development of New Antibiotics
Sujata M. Bhavnani, PharmD, MS - Vice President
ICPD, Latham, NY
Mathematical Modeling: Software Choices
Jurgen B. Bulitta
Monash Univ. and SUNY-Buffalo, Parkville, Australia

2013 - ICAAC WORKSHOPS

| Ursula Theuretzbacher | Activities - Workshops

ICAAC Workshops 2013

Monday, September 9, 2013 at the Colorado Convention Center, Denver, USA, 8:30AM - 4:30PM

Workshop.53-01.Introduction to Pharmacokinetics/Pharmacodynamics 

Workshop Convener
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Workshop Convener
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Introduction to Pharmacokinetics
Hartmut Derendorf, PhD - Professor
Univ. of Florida Coll. of Pharmacy, Gainesville, FL.
Introduction to Pharmacodynamics
Ursula Theuretzbacher, PhD - Principal
Ctr. for Anti-Infective Agents, Vienna, Austria.
Linking Pharmacokinetics and Pharmacodynamics
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Introduction to In vitro Infection Models
Roger L. Nation, PhD - Professor
Monash Univ., Melbourne, Australia.
Introduction to In vivo Infection Models
William A. Craig, MD - Emeritus Professor
Univ. of Wisconsin, Madison, WI.

Workshop.53-03.Application of Pharmacokinetic/Pharmacodynamic Models

Workshop Convener
Sujata M. Bhavnani, PharmD, MS - Vice President
ICPD, Latham, NY.
Workshop Convener
Alan Forrest, Pharm D - Research Professor and Senior Director of Pharmacometrics
Univ. at Buffalo and Inst. of Clin. Pharmacodynamics, Buffalo, NY.
Use of Population Pharmacokinetic Modeling in Therapeutic Drug Monitoring
Alexander A. Vinks, PharmD, PhD - Professor
Univ. of Cincinnati, Cincinnati, OH.
Predicting Pharmacokinetic Variability Using Stochastic Simulation
Sujata M. Bhavnani, Pharm.D., M.S. - Vice President
ICPD, Latham, NY.
Modeling and Prediction of Anti-Infective Activity
Alan Forrest, Pharm D - Research Professor and Senior Director of Pharmacometrics
Univ. at Buffalo and Inst. of Clin. Pharmacodynamics, Buffalo, NY.
Resistant Breakpoint Determination
Alasdair MacGowan, MD - Professor
North Bristol NHS Trust & Univ. of Bristol, Bristol, United Kingdom.
Pharmacokinetics/Pharmacodynamics to Characterize and Overcome Resistance
George Drusano, MD - Professor and Director
Univ. of Florida, Orlando, FL.

Workshop.53-02.Clinical Pharmacokinetics/Pharmacodynamics

Workshop Convener
Vincent H. Tam, PharmD - Professor
Univ. of Houston Coll. of Pharmacy, Houston, TX.
Workshop Convener
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Clinical Application of Pharmacokinetics and Pharmacodynamics
Vincent H. Tam, PharmD - Professor
Univ. of Houston Coll. of Pharmacy, Houston, TX.
Combination Therapy
Johan Mouton, MD, PhD - Professor
Radboud Univ. Nijmegen Med. Ctr., Nijmegen, Netherlands.
Dosing in Special Patient Populations
Markus Zeitlinger, MD - Associate Professor
Med. Univ. Vienna, Vienna, Austria.
Individualized Dosing and Therapeutic Drug Monitoring
Jason A. Roberts, PharmD, PhD - Consultant Clinical Pharmacist
Royal Brisbane and Women’s Hosp. & Univ. of Queensland, Brisbane, Australia.
Clinical Study Design Based Upon Pharmacokinetics/Pharmacodynamics
Sujata M. Bhavnani, Pharm.D., M.S. - Vice President
ICPD, Latham, NY.

Workshop.53-04.Pharmacokinetics/Pharmacodynamics in Non-Bacterial Infections

Workshop Convener
David R. Andes, MD - Professor
Univ. of Wisconsin, Madison, WI.
Workshop Convener
George Drusano, MD - Professor and Director
Univ. of Florida, Orlando, FL.
Anti-Fungal Pharmacokinetics/Pharmacodynamics
David R. Andes, MD - Professor
Univ. of Wisconsin, Madison, WI.
Anti-Tuberculosis Pharmacokinetics/Pharmacodynamics
Tawanda Gumbo, MD - Associate Professor of Medicine
UT Southwestern Med. Ctr., Dallas, TX.
Anti-Viral Pharmacokinetics/Pharmacodynamics
George Drusano, MD - Professor and Director
Univ. of Florida, Orlando, FL.
Anti-Malaria Pharmacokinetics/Pharmacodynamics
Nicholas J. White, MD, FRS - Professor of Tropical Medicine
Mahidol Univ. and Oxford Univ., Bangkok, Thailand.

 

 

2012 - ICAAC WORKSHOPS - San Francisco

| Ursula Theuretzbacher | Activities - Workshops

ICAAC Workshops 2012
Saturday, September 8, 2012, San Francisco, USA

Moscone Center (Esplanade Ballrooms)

Workshop 01 (Derendorf/Mouton) Basics of Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents

8:30 - 8:40 am

 Conveners

 Introduction
8:40 – 9:10 am

 H. Derendorf

 Introduction to PK/PD + discussion
9:10 – 9:40 am

 J. Mouton

 PK/PD indices + discussion
9:40 - 10:10 am

 U. Theuretzbacher

 Protein Binding/Tissue Distribution + discussion
10:10 - 10:30 am

 Break
10:30 – 11:00 am

 R. Nation

 In vitro models + discussion
11:00 - 11:30 am

 W. Craig

Animal models + discussion
11:30 – 12:00 am

 A. MacGowan

 In vitro resistance + discussion

 

Workshop 02 (Mouton/Theuretzbacher) Clinical Relevance of Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents

1:00 – 1:10 pm

 Conveners

 Introduction
1:10 – 1:40 pm

 J. Mouton

 Clinical applications of PK/PD + discussion
1:40 – 2:10 pm

 M. Zeitlinger

 Drug exposure at infection site + discussion
2:10 – 2:40 pm

 S. Bhavnani

 Clinical study design based on PK/PD + discussion
2:40 – 3:00 pm

 Break
3:00 – 3:30 pm

 U. Theuretzbacher

 Clinical resistance  + discussion
3:30 – 4:00 pm

 D. Andes

PK/PD of antifungals + discussion
4:00 – 4:30 pm

 P. Tulkens

 Dosing in specific situations + discussion

 

Workshop 51-03 (Tam/Vinks) Introduction to PK/PD Modeling of Anti-Infective Agents

8:30 - 8:40 am

 Conveners

 Introduction
8:40 – 9:10 am

 A. MacGowan

 Approach to clinical breakpoints + discussion
9:10 – 9:40 am

 V. Tam

 PK/PD modeling of resistance + discussion
9:40 - 10:10 am

 J. Crandon

 PK/PD approaches in drug development + discussion
10:10 - 10:30 am

 Break
10:30 – 11:00 am

 A. Vinks

 Population PK/PD modeling of anti-infective agents + discussion
11:00 - 11:30 am

 A. Forrest

 Modeling of anti-infective activity + discussion
11:30 – 12:00 am

 S. Bhavnani

 Monte Carlo Simulations + discussion

 

Workshop 51-04 (Drusano/Derendorf) Advanced PK/PD Modeling of Anti-Infective Agents with Practical Examples

1:00 – 1:10 pm

 Conveners

 Introduction
1:10 – 1:55 pm

 H. Derendorf

 PK/PD based on kill curves + discussion
1:55 – 2:40 pm

 A. Forrest

 Modeling of anti-infective activity + discussion
2:40 – 3:00 pm

 Break
3:00 – 3:45 pm

 G. Drusano

 PK/PD in drug development + discussion
3:45 – 4:30 pm

 J. Bulitta

 PK/PD models of resistance + discussion