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Annual Meetings

  • ISAP Annual Meeting 2024

    We were honoured to be joined by Professor Gunnar Kahlmeter, sharing his inspiring career journey.

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    Continuing the custom, we had our ISAP Young Investigator session, chaired by Drs Vincent Aranzana-Climent (France), Rekha Pai Mangalore (Australia), Alina Nussbaumer-Pröll (Austria) and Sue C. Nang (Australia). We were thrilled to hear 15 exciting presentations from our young investigators.

    Oral Presentations

    Presenter

    Title

    Irene Hernández-Lozano

    Uppsala University, Sweden

    Model-informed drug-development for antimicrobials: translational PKPD modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections

    Zhi Ying Kho

    Monash University, Australia

    Polymyxins differentially remodel human macrophage proteomic landscape in the presence and absence of bacterial infection

    Noémie Prebonnaud

    Université de Poitiers, Inserm U1070, France

    Linezolid and meropenem in vitro efficacy in artificial cerebrospinal fluid compared to Mueller-Hinton broth in hollow-fiber

    Aneeq Farooq

    University of Hamburg, Germany

    A pharmacometric model assessing the synergistic effect of bacteriophage-polymyxin combination therapy in a clinical multidrug-resistant K. pneumoniae isolate in vitro

    Alice Terrill

    Monash University, Australia

    Mechanism-based mathematical modelling predicts the effects of ciprofloxacin and meropenem on Pseudomonas aeruginosa with different resistance mechanisms in cases where PK/PD indices cannot

    Siobhonne Breen

    Monash University, Australia

    Ceftolozane/tazobactam and meropenem, in monotherapy and combination, against ST235 clone Pseudomonas aeruginosa isolates in the dynamic in vitro hollow-fibre infection model

    Rapid-Fire Talk

    Presenter

    Title

    Farras Daffa Imtiyaz

    Université de Poitiers, Inserm U1070, France

    Adjuvant-loaded lipid nanoparticles to increase the susceptibility of Acinetobacter baumannii to colistin

    Jan Naseer Kaur

    University at Buffalo, USA

    Fine tuning polymyxin B based regimens to effectively tackle the growing threat of pan drug resistant Klebsiella pneumoniae

    Dominika Fuhs

    Monash University, Australia

    Mechanism-based modelling approach to simultaneously characterise the effects of single and multiple resistance mechanisms on bacterial killing and resistance emergence of Pseudomonas aeruginosa in response to meropenem

    Adrien Baillod

    Université de Poitiers, Inserm U1070, France

    Synergistic interaction between amphotericin B and azoles against Candida guilliermondii using pharmacodynamics-modelling approach

    Jess Tait

    Monash University, Australia

    Multi-omics informed mechanism-based model of meropenem plus tobramycin against clinical hypermutable Pseudomonas aeruginosa isolates in a hollow fibre infection model

    Annika Koumans

    Leiden University, Netherlands

    Interspecies interactions of cystic fibrosis-associated pathogens alter antibiotic pharmacodynamics

    Johannes Starp

    LMU University Hospital, LMU Munich, Germany

    Optimizing linezolid therapy in critical care: combining therapeutic drug monitoring and model-based approaches enhances target attainment

    Braira Wahid

    Monash University, Australia

    Tackling AMR with phage training: in vitro and in vivo evaluation of a trained phage against multidrug resistant Klebsiella pneumoniae

    Samar Ahmed

    California Northstate University, USA

    Potential synergy of fluoxetine and antimicrobials

    Many congratulations to Mr Aneeq Farooq and Ms Annika Koumans for wining the best oral presentation and rapid-fire talk awards, respectively!

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    Moving forward, Professor Juergen Bulitta (USA) will serve as the President for the term 2024 – 2026, with Professor Lena Friberg (Sweden) as the President-Elect.

    It has been an amazing reunion for our ISAP community, and we look forward to seeing you again soon!

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  • ISAP Annual Meeting 2023

    This year, we were honoured to be joined by Professor Oana Ciofu as a Keynote Speaker to kick off the meeting with an insightful talk on the efforts to combat biofilm infections.

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    The meeting was followed by the traditional ISAP Young Investigator session, chaired by Dr. Vincent Aranzana-Climent, Dr. Iris Minichmayr and Dr. Sue C. Nang. It was fascinating to hear about the ground-breaking research conducted by our talented ISAP Young Investigators.

    Presenter

    Title

    Noémie Prébonnaud

    Université de Poitiers, France

    Predicting antibacterial efficacy of linezolid on Staphylococcus aureus in cerebral infections using in vitro hollow fiber model and pharmacokinetic-pharmacodynamic modeling

    Aneeq Farooq

    University of Hamburg, Germany

    Pharmacokinetic/pharmacodynamic studies of meropenem combined with fosfomycin in a clinical K. pneumoniae isolate expressing KPC-2 carbapenemase and fosfomycin resistance

    Mathilde Lacroix

    Université de Poitiers, France

    Transcriptomic data to support in vitro semi-mechanistic PK/PD modelling of polymyxin B against Acinetobacter baumannii

    Chenyan Zhao

    Uppsalla University, Sweden

    Characterizing bacterial growth and killing kinetics of RG6006 using in vitro and in vivo time-kill studies and mechanism-based pharmacokinetic-pharmacodynamic (PKPD) modeling

    Thomas D. Nguyen

    University at Buffalo, USA

    Developing a mechanistically informed population pharmacokinetic model of vancomycin in patients undergoing intermittent hemodialysis

    Augustine Koh

    Melbourne University, Australia

    Investigating Leu10Teixobactin combinations with glycopeptides against multidrug-resistant Gram-positive pathogens

    Eva Wehrhahn

    Uppsalla University, Sweden

    Quantification of antibiotic-induced changes in bacterial counts and morphology using timelapse microscopy, image analysis, machine learning and pharmacokinetic-pharmacodynamic modelling

    Malin Andersson

    Freie Universität Berlin, Germany

    Beyond the standard ratio: Quantitative exploration of the effect of piperacillin with varying tazobactam concentrations

    Gert-Jan Wijnant

    Université catholique de Louvain, Belgium

    Population pharmacokinetics and dosing simulation of the β-lactam temocillin in liver-transplanted pediatric patients

    Hélène Thirot

    Université catholique de Louvain, Belgium

    Linezolid toxicity in clinical practice: Towards a better detection of at-risk patients? Interim analysis of a prospective multicentric study

    Maria Sanz-Codina

    Medical University of Vienna, Austria

    Plasma and soft tissue pharmacokinetics of cefiderocol in healthy volunteers

    Congratulations to the winners of the Young Investigator session:

    Oral presentation: Mr. Aneeq Farooq (University of Hamburg, Germany)

    ISAP at ECCMID 2023 Lower Qual 3

    Rapid fire talk: Dr. Gert-Jan Wijnant (UCLouvain, Belgium)

    ISAP at ECCMID 2023 Lower Qual 2

    We were delighted to see many of you in Copenhagen and we look forward to seeing you again next year!

    ISAP at ECCMID 2023 Lower Qual 5

  • Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

    A 2 day course on PK/PD of anti-infectives was held as a pre-meeting to ECCMID at April 20 -21 2022 in Lisbon, Portugal. The course was organized in collaboration with EPASG and very well attended.

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    The program of the course can be found here

    ISAP General and Scientific Meeting

    Immediately following the educational course, we held our general meeting and reflected on our scientific and educational acitivities of the past two years, followed by the traditional ISAP Young investigator session, chaired by Dr. Alina Nussbaumer-Pröll (Vienna) and Dr. Vincent Aranzana-Climent (Poitiers). 

    The slides of the general meeting can be found below. Access is restricted to ISAP members (please login to view attachment).

    The following Young Investigators presented their work:

    First name

    Last Name

    Title

    Aneeq

    Farooq

    Interaction screening of ceftazidime-avibactam and tigecycline against six clinical and nine isogenic E. coli and K. pneumoniae strains expressing carbapenemases

    Wisse

    Van Os

    Impact of individual ascitic fluids on bacterial growth and ceftriaxone effect in an in vitro model of spontaneous bacterial peritonitis

    Nicole

    Zimmermann

    Integrated in vitro approach to understand the exposure-effect relationship of fosfomycin against Escherichia coli

    Amaury

    O'Jeanson

    A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against β-lactamase-producing Gram-negative bacteria

    Jinxin

    Zhao

    PhageGE: An Interactive Web-based R Shiny Application for Bacteriophage Pharmacology

    Sue

    Nang

    Elucidating the pharmacokinetics/ pharmacodynamics of bacteriophage therapy against Pseudomonas aeruginosa using a mouse bacteraemia model

    Romain

    Aubry

    Semi-mechanistic PKPD modelling of ceftazidime/avibactam and colistin combination against five multidrug resistant Klebsiella pneumoniae isolates

    Mathilde

    Lacroix

    In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

    Matthias

    Gijsen

    Model-based TDM of vancomycin: a retrospective comparison with routine TDM-based dosing

    Gert-Jan

    Wijnant

    Pharmacokinetics and PK/PD of temocillin in non-ICU urinary tract infection patients with various stages of renal insufficiency

    Tim

    Ewoldt

    Large variability of unbound active fraction of ceftriaxone in contrast to ciprofloxacin in plasma of critically ill patients

    Maria

    Sanz Codina

    Relationship between pharmacokinetic/pharmacodynamic target attainment and microbiological outcome in critically ill COVID-19 patients with documented Gram-negative superinfections treated with meropenem continuous infusion

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    ISAP Young Investigators

     

    The audience voted for the best Young Investigator presentations: 

    Wisse Van Os (Medical University of Vienna, Austria)

    Gert-Jan Wijnant (UCLouvain, Belgium)

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    The winner of the Young Investigator session Wisse van Os (3rd from left) and runner-up Gert-Jan Wijnant (3rd from right) together with the Young Investigator session chairs Alina Nussbaumer-Pröll and Vincent Aranzana Climent (right) and Sebastian Wicha (President of ISAP) and Markus Zeitlinger (Chair of EPASG) (left).

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    All attendees of the ISAP meeting.

  •  The ISAP 2021 meeting was held as a full day virtual conference in collaboration with EPASG on Friday, November 12 2021 - Saturday November 13 2021 as a online meeting.

    Program

    Friday November 12 2021
    13.00-13.10         Welcome on behalf of EPASG
    (CET)                     Markus Zeitlinger
     
    13.10-13.15         A Themed Issue in Honour of Professor Hartmut Derendorf in ‘Antibiotics’
    (CET)                     Francoise Van Bambeke
     
    13.15-15.15          Session I: Tribute to Hartmut Derendorf (Ursula Theuretzbacher, William Couet, Markus
    (CET)                      Zeitlinger)
    Amparo de la Peña: Hartmut Derendorf: Scientific Impact and Personal Legacy
    Teresa Dalla Costa: Microdialysis to investigate antimicrobials tissue penetration: lessons learned!!
    Günther Hochhaus: Hartmut Derendorf’s impact beyond antimicrobial pharmacology
    Jürgen Bulitta: Hartmut Derendorf’s impact on antimicrobial pharmacology over four decades and beyond
     
    15.15-15.30          Coffee break
    (CET)                                                      
     
    15:30-17.00         Session II: Viral PK/PD (Cornelia Landersdorfer, Lena Friberg, Sebastian Wicha)
    (CET)                     
    Isabelle Bekeredjian-Ding: Regulatory decision making on COVID-19 vaccines
    Ashley Brown: Nucleoside/Nucleotide Antiviral Therapy for the Treatment of COVID-19: It’s What’s on the Inside that Counts
    Ryan Vargo: Enhancing Antiviral Drug Development through Translation and Quantitative Pharmacology
    17.00-17.15         Coffee break        
    (CET)
    17.15-18.15         Young Investigator Session Part I (Francoise Van Bambeke, Alina Nussbaumer-Pröll)
    (CET)
     
    Saturday November 13 2021
    8.30-9.40              Young Investigator Session Part II (Sandrine Marchand, Elisabet Nielsen)
    (CET)
    9.40-10:00           Coffee break        
    (CET)
    10:00-11.15         Session III: Combination therapy (Alexia Chauzy, Thomas Tängdén)
    (CET)                     Cornelia Landersdorfer: PK/PD modelling as a tool to better understand drug-drug interactions in combinations
                                 Stephen H. Gillespie: A fresh look on drug combinations in TB
    11.15-12.00         Lunch break
    (CET)
    12.00-13.00         Pro/Con: Translating Preclinical Models to Clinical Outcomes (Jian Li, Zackery Bulman)
     (CET)                     Pro:        Sujata Bhavnani
                                  Con:        John Turnidge
    13.00-14.00         Pro/Con: To TDM or not to TDM? (Birgit Koch, Iris Minichmayr)
     (CET)                      Pro:        Angela Huttner
                                   Con:        Bruce Dalton
    14.00-14.15         Presentation of the Young Investigator Awards (Alina Nussbaumer-Pröll, Elisabet Nielsen)
    (CET)               
          
    Closing on behalf of ISAP
    Sebastian Wicha
     

     group 1 2021

    group 2 2021

     

     

    Young Investigator session awards

    As per the ISAP tradition, Young Investigators presented their research in the traditional Young Investigator session. The presentation topics ranged from pre-clinical, mechanistic PK-PD studies up to clinical applications of PK-PD. All research was presented very comprehensively and to the highest scientific standards.

    The attendees voted the best three presentations who recieved the Young Investigator Awards 2021:

    Winner:

    Vincent Aranzana-Climent (Uppsala University, Sweden)

     Runner-ups:

    Khalid Iqbal (University of Hamburg, Germany)                              Anselm Jorda (Medical University of Vienna, Austria)

     first winner 2021  second winners 2021

     

  •  

    The ISAP 2020 meeting was held as a virtual meeting on Friday, September 18th, 12:00pm to 2:00pm (CEST) as an online meeting

    Schedule 

    11:30 to 12:00pm    Council meeting (closed)
    12:00 to 12:30pm   General Meeting: Welcome, ISAP discussion, and New Officers
    12:30 to 2:00pm Young Investigator Session

      

    ISAP Council and General Meeting

    Retirement of Council members

    The Council for the term 2018-2020 comprised:

    • Brian Tsuji (President)
    • Sebastian Wicha (President-Elect)
    • Zackery Bulman (Treasurer)
    • Jian Li (Secretary)
    • Council members: Hartmut Derendorf, Lena Friberg, Elizabeth Lakota, Justin Lenhard, Elisabet Nielsen, Roger Nation, Ursula Theuretzbacher, Markus Zeitlinger

    In the light of many new nominations, Roger Nation, Hartmut Derendorf, Ursula Theuretzbacher, Elizabeth Lakota and Justin Lenhard retired from Council to provide new members the opPicture 2portunity to serve ISAP. With Ursula, Hartmut, and Roger, three former presidents of ISAP and longstanding ISAP members leave the Council.

    Brian thanked all retiring Council members for their outstanding services to ISAP, without whom the society would not be the same as it is today.

    All members thanked Brian Tsuji for his amazing work he has done as President and beyond. He provided a collegial leadership to ISAP, was a huge supporter of all Young Investigator activities and organized scientific symposia and strategically liaised new collaborations for ISAP. THANK YOU, Brian!

    Election of Council members for the term 2020-2022

    • Sebastian Wicha (President)
    • Jian Li (President Elect)
    • Zack Bulman (Treasurer)
    • Elisabet Nielsen (Secretariat)
    • Iris Minichmayr (Secretariat)
    • Council members: Lena Friberg, Markus Zeitlinger, Brian Tsuji, Jürgen Bulitta, Cornelia Landersdorfer, Alina Nussbaumer-Pröll, Nicholas Smith

    It is a great to have so many new members on board to join and shape the future of ISAP!

     

    Update on ISAP activities

    PKPD Webinar (in collaboration with EPASG) – SAVE THE DATE: November 24 2020 –

    In collaboration with EPASG, there will be a webinar on “Modeling SARS-Cov-2 viral dynamics to optimize therapy”, by Dr Jeremie Guedj from INSERM, Paris, France held on November 24 2020 4PM CET. The details to join the meeting will be provided in another newsletter. Welcome!

     

    ASCPT Pre-Conference 2020

    A pre-conference to the ASCPT meeting titled “Translational and Clinical Pharmacology Advances in Anti-Infective Development” was planned for March 18 2019 in collaboration with ASCPT and SIDP. The ISAP contribution was organized by Hartmut Derendorf. A number of ISAP speakers (Lena Friberg, Corneial Landersdorfer, Sebastian Wicha) were scheduled for contributing presentations to the pre-conference. No follow up meeting is planned at this stage, but instead a call for papers to a special issue on Anti-Infectives has been launched in Clinical Pharmacology & Therapeutics. Read more here, in case you wish to contribute.

    Antimicrobial Pharmacology at ISICEM 2020 – scheduled for Autumn 2021

    ISAP contributed a clinically-oriented session on “Pharmacology of Antibiotics” to the International Symposium on Intensive Care & Emergency Medicine (ISICEM). Iris Minichmayr and Sebastian Wicha were scheduled to contribute presentations on PKPD relationships of antibiotics and interactive case studies for dose individualization. At this stage, the conference is re-scheduled for March 2021. Read more here, in case you are interested to attend.

    Face-to-face Meeting(s) 2021

    As you all know, the current situation makes it difficult to predict if we can meet in person next year. Potential candidates for a face-to-face meeting are pre or post ECCMID (Vienna, 9-12 July 2021) or a US-based meeting. We will keep you informed.

    Online meetings

    We are planning a series of regional online meetings to foster scientific exchange between ISAP members. Stay tuned.

     

    Scientific Meeting of ISAP – Young Investigator session

    As per the ISAP tradition, also in our virtual meeting, Young Investigators presented their research in the traditional Young Investigator session. The presentation topics ranged from pre-clinical, mechanistic PK-PD studies up to clinical applications of PK-PD. All research was presented very comprehensively and to the highest scientific standards. Congratulations to all Young Investigators!

    Presenter Title
    Zhi Ying Kho Omics of the tripartite relationships among Acinetobacter baumannii, polymyxin and macrophage
    Jinxin Zhao Genome-scale metabolic modelling of multidrug-resistant Acinetobacter baumannii revealed significant metabolic changes during bloodstream infection in mice
    Niklas Krömer Adaptive optimal design to support efficient high throughput screening of in vitro pharmacodynamic drug interaction studies
    Alina Nussbaumer-Pröll Comparison of dosage strategies of meropenem vs. Escherichia coli and Pseudomonas aeruginosa
    Tan Xing Activity of simulated ELF concentrations of inhaled and intravenous tobramycin and polymyxin B against Pseudomonas aeruginosa in an in vitro dynamic biofilm model
    Hubert Chjua Antiretroviral and β-lactam Combinations against NDM-Producing Klebsiella pneumoniae: Repurposing Zidovudine as Salvage Therapy 
    Anders Thorsted Translational modelling of innate immune response following lipopolysaccharide challenge: from piglets to humans 
    Josefine Schulz Feasibility investigations of simultaneous microdialysis of voriconazole and its N-oxide metabolite
    Luis Ilia Identification and quantification of microdialysis variability using an integrated in vitro, ex vivo and in silico approach.
    Anne-Grete Märtson Caspofungin weight-based dosing 

            

  • EPASG-EUCAST-ISAP course

    Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

    A 2 day course on PK/PD of anti-infectives was held as a pre-meeting to ECCMID at April 11 -12 2019 in Rotterdam, The Netherlands. The course was organized in collaboration with EPASG and EUCAST and very well attended.

    EPASG course

     

    Scientific Meeting of ISAP

    Standing on the Shoulder of Giants: A Tribute to Alan Forrest.

    This year’s ISAP scientific meeting started with a session remembering Alan Forrest, who passed away in August 2018. Alan was a wonderful friend, mentor, colleague and a true inspiration to our community and beyond. In this open session, a number of ISAP members shared personal and scientific memories of Alan with the attendees.

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    Brian Tsuji Roger Nation

     

    Young Investigator Session

    Immediately following the educational course, a Scientific Meeting was held in association with EPASG. As per the ISAP tradition, the meeting focused on the presentation of the research of Young Investigators. With 12 presentations from Young Investigators, a diverse group of studies in antimicrobial PKPD was discussed by the knowledgeable speakers. The slides of the presentations can be found in the Archive (available after login for ISAP members).

    Young Investigator presentations:

    Presenter

    Title

    Vincent Aranzana-Climent

    Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii

    Xiaoting Hua

    Formation and evolution of multi-drug resistance plasmid in Proteus mirabilis

    Ahmed M. Fathalla

    Polymyxins co-localise with different cellular organelles in human macrophages

    Jessica R. Tait

    Piperacillin/tazobactam plus tobramycin against a clinical Pseudomonas aeruginosa isolate: optimising combination dosage regimens in a dynamic in vitro infection model

    Johanna Seeger

    Exploring the exposure-effect relationship of levofloxacin against fluoroquinolone resistant Escherichia coli isolates in a dynamic in vitro infection model

    Hajira Bilal

    Pharmacodynamics of meropenem - tobramycin combination dosage regimens against clinical hypermutable Pseudomonas aeruginosa at simulated epithelial lining fluid concentrations in a dynamic biofilm model

    Shachi Mehta

    “PK/PD” type of modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus 

    Alina Nussbaumer-Pröll

    Comparison of antimicrobial activity and pathogen mutation prevention of originator and generics of cefepime, linezolid and piperacillin-tazobactam

    Khalid Iqbal

    Towards target site-specific breakpoints combining microdialysis, time-kill curves and physiologically based pharmacokinetic (PBPK) modelling: A case study with moxifloxacin

    Sebastian Franck

    Boosting the immune system to enhance amoxicillin activity: Insights provided by semi-mechanistic PK/PD modelling

    Jinxin Zhao

    Battle to the end: uncover the interplay among the host, pathogen and polymyxin in a murine Acinetobacter baumannii bacteremia model by the dual transcriptome analysis

    Dinh H. Vu

    Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: population pharmacokinetic modelling and simulation

    Congratulations to Sebastian Franck (Freie Universität Berlin / University of Hamburg, Germany) who received the newly introduced Alan Forrest Young Investigator Award for the overall best presentation. Congratulations to Shachi Metha (University of Poitiers, France) and Alina Nussbaumer-Pröll (Medical University of Vienna, Austria) for winning the two runner-up awards in this session.

     IMG 0191

    Markus Zeitlinger (Chair of EPASG), Zackery Bulman and Sebastian Wicha (Chairs of the ISAP Young Investigator Session), Shachi Metha (Young Investigator Award winner), Thomas Tängdén (Treasurer of EPASG), Sebastian Franck (Alan Forrest Young Investigator Award winner), Alina Nussbaumer-Pröll (Young Investigator Award winner) and Brian Tsuji (President of ISAP).

    ISAP Friday April 12 2019

    All participants of the 2019 ISAP Meeting

    Social Reception

    The meetings above were followed by a social gathering in the lobby of the conference hotel Blijdorp Rotterdam to discuss latest news on PK-PD and beyond and to meet old and new colleagues and friends.

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    IMG 0161 IMG 0202
       

     

  • ISAP Council Meeting and General Meeting

    Retirement of Council members

    The current Council was elected in 2016 and comprises:

    • Roger Nation (President)
    • Brian Tsuji (President Elect and Treasurer)
    • Ursula Theuretzbacher (Immediate Past President)
    • Lena Friberg and Sebastian Wicha (Joint Secretariat)
    • Council members: Hartmut Derendorf, Justin Lenhard, Johan Mouton, Vincent Tam and Markus Zeitlinger
    • Young Investigator Liaison: Justin Lenhard and Sebastian Wicha

    In view of the healthy number of people who nominated for the next Council, Johan Mouton and Vincent Tam kindly offered to retire from Council to provide opportunity for others to serve ISAP.

    An amazing feat is that Johan has been on Council for 20 years, with a substantial portion of that time serving as a member of the executive. Indeed, Johan was President Elect of ISAP from 2000 to 2002, President from 2002 to 2004 and Immediate Past President from 2004 to 2006. 

    Vincent has served on Council for 10 years, with 8 of those years as Treasurer. Both Johan and Vincent have made an enormous contribution not only to ISAP Council but also to the activities of ISAP more generally (e.g. as key contributors to ISAP educational workshops and conference symposia) and to the discipline.

    On behalf of all members of ISAP, Roger and other Council members would like to thank Johan and Vincent for their dedicated service and collegiality, and for their kind offer to provide ongoing support to the Councils of the future. Roger would like to take this opportunity to thank all members of ISAP Council for their wonderful support over the last two years. Of special note is Brian who has been an outstanding President Elect; he will be equally outstanding when he takes on the role of President. Brian would like to thank Roger for the work he has done as President. He has provided compelling leadership to ISAP which has expanded membership, organized key educational symposia, liaised strategic collaborations and allowed ISAP to reach new heights of excellence. Roger’s hard work, dedication and passion for ISAP is extremely inspiring to us all.  With most sincere gratitude from all of us to our fearless and amazing leader – Roger Nation!

    Election of Council members for the next two years

    There was an excellent response to the call for nominations for membership of the next ISAP Council and for the executive officer positions. The composition of the next Council is as follows:

    • Brian Tsuji (President)
    • Sebastian Wicha (President Elect)
    • Roger Nation (Immediate Past President)
    • Jian Li (Secretary)
    • Zack Bulman (Treasurer)
    • Council members: Hartmut Derendorf, Lena Friberg, Elizabeth Lakota, Justin Lenhard, Elisabet Nielsen, Ursula Theuretzbacher and Markus Zeitlinger

    It is truly wonderful to have Jian, Zack, Elizabeth and Elisabet join ISAP Council. The membership of the new Council was ratified by the ISAP members who attended the General Meeting in Madrid. The new Council will commence its term in June 2018.

    ISAP Honorary Life Membership Recipient: Professor Otto Cars

    At the General Meeting in Madrid, Professor Otto Cars was announced as the recipient of Honorary Life Membership of ISAP. In accordance with ISAP Bylaws, appointment to Life Membership was made on the recommendation of Council. Below is a very brief summary of Otto’s outstanding career, including his key role in creating and nurturing ISAP and his contribution to optimizing the use of antimicrobials and preserving their usefulness for generations to come.

    • Otto Cars was a founding member of ISAP
    • Along with Dr William Craig, Otto organized a landmark meeting in Copenhagen in 1989 that led to ISAP being created in 1991 (see black and white photo)
    • Otto was the second President  of ISAP (1994 - 1996) following the term of William Craig as the initial President (1991 - 1994)
    • Otto became a specialist in infectious diseases in the early 1970s
    • He was appointed Head of the Department of ID at Uppsala University Hospital 1991-1999
    • In 2003, Otto became Professor of ID at Uppsala University
    • Otto’s research over the years has focussed on PK and PD of antibiotics, optimal antibiotic dosing regimens, resistance epidemiology and antibiotic policies
    • Otto has published extensively and is highly respected for the quality and the impact of his work
    • He initiated and/or was a driving influence in numerous Swedish, European and international initiatives to preserve the usefulness of antibiotics (e.g. Member of the WHO Strategic and Technical Advisory Group on Antimicrobial Resistance (STAG-AMR); Founding Director of ReAct in 2005, and since 2013 he is now a senior strategic adviser; Expert member on the recently created UN / WHO  Interagency Coordination Group on Antimicrobial Resistance)
    • Otto has been the recipient of numerous awards for his services to medicine and science (e.g. he was awarded the highly prestigious King’s Medal in 2015)

    Interactions with other organizations

    On behalf of ISAP, Ursula Theuretzbacher and Sebastian Wicha delivered a 1-hour interactive workshop to ca. 300 participants at the 18th International Congress on Infectious Diseases held in Buenos Aires in March. After an introduction into PK/PD concepts and targets, participants were actively involved in an interactive session. On their mobile devices or laptops, they used the TDMx web application as an example of a precision dosing tool to work on several tasks around dose individualization of β-lactam antibiotics. The session was a great success and the diverse audience (mainly physicians, pediatricians, pharmacists, microbiologists) from all parts of the world seemed to be able to follow the instructions and to experience how PK and PD variables influence dosing decisions.
    At the ASM Microbe conference in Atlanta USA in June, ISAP is delivering a pre-conference workshop entitled ‘Introduction to Pharmacokinetics-Pharmacodynamics: A Basic Primer’. The workshop is being delivered by Brian Tsuji, Hartmut Derendorf, Elizabeth Lakota, Vincent Tam and Roger Nation. A Young Investigator night out for ISAP in collaboration with ISoP is being planned by Elizabeth Lakota on Friday June 8 in the late evening. More details will be posted on the ISAP website as the date approaches.
    Following the ECCMID meeting in Madrid this year, ISAP worked with EPASG to deliver an oral presentation session within the scientific program of the 3rd International Conference on Polymyxins. ISAP is actively engaged in planning a joint initiative with EPASG and EUCAST to hold an educational / scientific meeting as a satellite to the ECCMID meeting to be held in Amsterdam in April 2019. ISAP and EPASG have held highly successful joint meetings in the past, including the day prior to the ECCMID meeting in Vienna last year.
    ISAP Council is very eager to join with other organizations in submitting proposals for symposia and educational workshops at major conferences in various parts of the world. A number of possibilities are under active consideration.

    Endorsement of Polymyxin Dosing Guidelines

    A unique opportunity for ISAP presented itself to endorse the Polymyxin Guidelines which will be published in Pharmacotherapy and will appear as executive summaries in other journals. ISAP will be endorsing the guidelines along with 6 other international organizations. The guidelines have been accepted by Pharmacotherapy and will be published soon.

    ISAP finances and membership

    The financial situation of ISAP is healthy and the membership is growing. However, it is very important for members to respond to the call for payment of the annual membership fee. ISAP is not a large organization and it is a time-consuming challenge to send reminder emails to members to prompt them to pay their annual membership subscription. In this regard, the cooperation of all members would be greatly appreciated. It would also be helpful if you would assist in recruiting new members from within your institutions and networks of scientific and clinical colleagues.

    Scientific Meeting of ISAP

    Immediately following the General Meeting in Madrid, a Scientific Meeting was held in association with EPASG. As per the ISAP tradition, the meeting focused on the presentation of the research of Young Investigators. With 13 presentations from Young Investigators, a diverse group of studies in antimicrobial PKPD was discussed by the knowledgeable speakers. Congratulations to Iain Abbott, Astrid Brӧker, and Nicholas Smith for receiving Young Investigator Awards for their excellent presentations.


    All participants of the 2018 ISAP Meeting


    Justin Lenhard (chair of the Young Investigator session), Roger Nation (President of ISAP), Iain Abbott, Astrid Bröker and Nicholas Smith (Young Investigator Awardees) and Sebastian Wicha (chair of the Young Investigator session).

    Social Reception

    The meetings above were followed by a social gathering held in collaboration with the 3rd International Conference on Polymyxins, EPASG and the Spanish Infectious Diseases Society. Approximately 100 people attended this function which provided the opportunity for ISAP members to socialize with their colleagues, meet potential new collaborators and enjoy light appetizers and liquid refreshments.


     

    Young Scientist Night Out in Madrid

    The night prior to the General Meeting young scientists who participate in ISAP were invited to an informal gathering to network and enjoy the nightlife of Madrid. Over 10 attendees met at the Del Diego Cocktail Bar to mingle and make new connections with peers in the field. Considering the success of the event, ISAP will likely host similar functions in conjunction with future meetings.

     

  • ISAP-EPASG Conference in Vienna a Major Success

    On 21 April, the day before the start of the 2017 ECCMID meeting, ISAP held a joint one-day conference with EPASG (the ESCMID PK/PD of Anti-infectives Study Group). The conference was entitled ‘Anti-infective PK/PD: Integrating Knowledge and Innovating Therapies’ and was held in the historic Old General Hospital Vienna. The program included sessions on key topics such as antimicrobial resistance, combination therapy and the role of the immune system. Informative and entertaining ‘pro’ / ‘con’ debating sessions on topics such as the future role of modelling versus clinical studies in the development and optimization of dosing of antimicrobials enhanced the program. A special feature of the day’s activities was a ‘Young Investigator’ session, which included presentations from 16 up and coming researchers, the largest number ever for such an ISAP session. All young investigators performed very well and the judges had great difficulty in deciding the recipients of awards. Overall, the first-placed awardee was Tobias Heinrichs, while Iris Minichmayr, Amelia Deitchman, Alexia Chauzy and Nikolas Onufrak also received awards. The ‘Young Investigator’ session continued the ISAP tradition of providing a forum for the emerging researchers of our discipline to deliver oral presentations of their research in a supportive setting and receive constructive feedback. The conference was supported by Basilea and Roche (main sponsors) and Nabriva and AntibioTx (sponsors).

    IMG 7922

    There were 120 attendees at the conference, a capacity crowd for the venue. Members of ISAP and EPASG (note that members of ESCMID can apply for free membership of EPASG) received discounted registration for the conference. Attendees at the conference indicated that they greatly enjoyed the day of antimicrobial pharmacological science. The day concluded with a wonderful dinner at a lovely heuriger in Vienna, and the presentation of awards to young investigators (see photo). This social event was kindly supported by the Mayor of Vienna.

    The conference would not have been possible without the tireless efforts of our Viennese colleagues Markus Zeitlinger and Ursula Theuretzbacher (conference chairs), with support from Alina Proll. The contributions of all members of the conference organizing committee, the speakers and chairs, Jacqueline van der Meer (Congress Care) and the sponsors are gratefully acknowledged.

     IMG 7937

    Young Investigator awardees Tobias Heinrichs (3rd from left), Nikolas Onufrak (1st from left), Iris Minichmayr (5th from left), Alexia Chauzy (2nd from right) and Amelia Deitchman (1st from right) along with Justin Lenhard and Sebastian Wicha (4th and 3rd from right, Chairs of the Young Investigator session) and Markus Zeitlinger (4th from left) and Ursula Theuretzbacher (2nd from left).

    Link to programme

  • The 2015 ISAP symposium took place after the ICAAC and before the Polymyxin Conference in a wonderful conference site in La Jolla near San Diego. The first part of the symposium was dedicated to the memory of Prof. William Craig and looking back to the achievements of our field whereas the second part of the afternoon was dedicated to the future of anti-infective pharmacology. A planned publication will summarise our vision for the future of our field.
    Similar to previous years the short presentations of young investigators where interesting, well received and discussed. Seven presentations were selected for presentation. Three young investigators – Amelia N. Deitchman, Justin Lenhard and Sebastian Wicha were awarded with travel grants for their work and the presentations. Mentoring young researchers and providing a friendly and supportive environment for discussing their work is one of ISAP's main goals as well as organising workshops at major conferences.

    ISAP meeting 2015 young investigators w


    General Assembly: 1:00-2:00 PM

    Preliminary program - ISAP symposium:
    2:10-2:15 PM   Introduction
    Ursula Theuretzbacher, Paul Ambrose
      
    Looking back: Achievements in anti-infective pharmacology

    Chair: Francoise van Bambeke
    2:15-2:30 PM     David Andes: Tribute to Bill Craig
    2:30-2:50 PM   Paul Tulkens: Lecture in memoriam Bill Craig
    24 years of ISAP - Achievements in the PK/PD field
      
    Looking forward: A critical focus for the next decade - A roadmap for research from an
    anti-infective pharmacology perspective
    Chair: Hartmut Derendorf, Vincent Tam
    2:50-4:00 PM   - How can the discipline of anti-infective pharmacology contribute to optimizing antimicrobial use in the future?

    - What are the new horizons?

    - What are the critical preclinical, translational and clinical research questions?

    - What do we need in the anti-infective pharmacology toolbox, in addition to PK/PD?

    Short kick-off presentations intended to provoke discussion about the future of anti-infective pharmacology.
    Panellists are asked to briefly address one or more of the above questions.

    Structured panel discussion and audience participation
    Panellists: Lena Friberg, Jürgen Bullita, Brian Tsuji, Jian Li, George Drusano, Jason Roberts, Johan Mouton, Paul Ambrose
    4:00-4:20 PM   Networking coffee break
    4:20-5:45 PM   Presentations of young investigators
    Chair: Brian Tsuji
    5:45-5:50 PM   Farewell: Roger Nation, Ursula Theuretzbacher
    6:00 PM

      Networking reception

    Program download
    Presentations of young investigators

  • The annual meeting and post-ICAAC symposium took place on September 9th, 2014, 2:00-6:00 pm, Hemsley Fraser, Suite 900, 1615 M Street, NW, 20036 Washington DC, MD
    ISAP symposium-kl

    Program:
    12:00 - 1:00 pm
    1:00 - 1:45 pm
    ISAP Council Meeting
    ISAP General Meeting


    2:00 – 2:10 pm

    Welcome
    2:10 – 3:10 pm

    Scientific presentation and discussion

    PK/PD in the regulatory environment
    Joga Gobburu, University of Maryland, School of Pharmacy, former head of pharmacometrics at FDA

    3:10 - 3:40 pm

    Break / informal discussion

    3:40 – 5:40 pm

    Scientific presentations by junior investigators

    5:40- 6:00 pm

    Discussion and closing remarks


    Scientific presentations by junior investigators

     MW. Sadiq  A whole-body physiologically based pharmacokinetic model of ciprofloxacin for prediction of bacterial killing at the site of infection
     S. Aitken  Cefepime free minimum concentration to minimum inhibitory concentration ratio predicts clinical failure in patients with Gram-negative bacterial pneumonia
     T-P. Lim  Multiple combination bactericidal testing-guided therapy is effective in the treatment of extensively drug-resistant Gram-negative bacteria infections
     E. Bassères  Antibiotic activity against different Pseudomonas aeruginosa phenotypes in an artificial sputum medium biofilm model
     A. Sultan  Bayesian estimation of levofloxacin pharmacokinetics in patients with tuberculosis

    Online presentations (will be posted after ICAAC):
    A. Deitchman The synergism between tigecycline and tetracycline: A protein binding-based approach
    S. Wicha Pharmacodynamics of vancomycin or linezolid combined with meropenem against Staphylococcus aureus assessed by descriptive and semi-mechanistic modelling techniques

    Download program


  • The annual meeting and post-ICAAC symposium took place on September 13th, 2013, 2:00-6:00 pm in Denver, Collorado: Four Mile Historic Park, 715 S. Forest Street
    ISAP meeting 2013-kl

    Program:
    12:00 - 1:00 pm
    1:00 - 1:45 pm
    ISAP Council Meeting
    ISAP General Meeting


    2:00 – 2:10 pm

    Welcome
    2:10 – 3:20 pm

    Scientific presentation and discussion

    PK/PD approach in industry vs academic settings
    • Virna Schuck, AstraZeneca: PK/PD approach in industry
    • ISAP: PK/PD approach in academic settings (prepared comments)
    Discussion
    3:20 - 3:50 pm

    Break / informal discussion

    3:55 – 5:35 pm

    Scientific presentations by junior investigators

    5:40- 6:00 pm

    Discussion and closing remarks


    Scientific presentations by junior investigators
    Time Presenting author Title
    3:55pm Seyedmousavi Posaconazole Prophylaxis in Experimental Azole-resistant Invasive Pulmonary Aspergillosis
    4:20pm Trang Initial Dosing and an Adaptive Feedback Control Algorithm for Renal Replacement Patients during Drug Development
    4:45pm Vandevelde Combinations of moxifloxacin with bronchodilators are synergistic against S. pneumoniae in models of naïve and induced biofilms
    5:10pm Zhuang Characterization of the in vitro antimicrobial activity of vertilmicin alone and in combination with ceftazidime using a semi-mechanistic pharmacokinetic/pharmacodynamic model

    Registration on site:
    - ISAP members: free
    - Non-members: 100 Euro including one year ISAP membership
    Coffee, beverages and snacks will be served.


  • The Annual Meeting and post-ICAAC symposium took place on Wednesday, September 12th, 2012, Fort Mason Center, Marina Blvd & Buchanan St, San Francisco, USA

    • PK/PD special topic:
      Jason Roberts: Translational aspects of PK/PD tools for personalized dosing in the ICU
    • Forum for Young investigators: Brief presentations on PK/PD topics related to old and new anti-infectives
    Program:
    12:00 - 13:00

      13:00 - 13:45
      ISAP Council Meeting

    ISAP General Meeting
    14.00 - 14:05

    14:05 - 15.15
     
      Welcome

    Scientific presentation and discussion
    Jason Roberts: Translational aspects of PK/PD tools for personalized dosing in the ICU

    Discussion
    15.15 - 15.40   Break / Informal discussion
    15.40 - 17.55   Scientific presentations by junior investigators
    Discussion, feedback
    18.00   Closing remarks

    More information on the scientific presentations
    young investigators 2012
  • The Annual Meeting and post-ICAAC symposium took place on Tuesday, September 20th,
    Hyatt Regency, McCormick Place, Chicago, IL

    Program