hdr isap 2019

Annual meeting 2022

Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

A 2 day course on PK/PD of anti-infectives was held as a pre-meeting to ECCMID at April 20 -21 2022 in Lisbon, Portugal. The course was organized in collaboration with EPASG and very well attended.

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The program of the course can be found here

ISAP General and Scientific Meeting

Immediately following the educational course, we held our general meeting and reflected on our scientific and educational acitivities of the past two years, followed by the traditional ISAP Young investigator session, chaired by Dr. Alina Nussbaumer-Pröll (Vienna) and Dr. Vincent Aranzana-Climent (Poitiers). 

The following Young Investigators presented their work:

First name

Last Name

Title

Aneeq

Farooq

Interaction screening of ceftazidime-avibactam and tigecycline against six clinical and nine isogenic E. coli and K. pneumoniae strains expressing carbapenemases

Wisse

Van Os

Impact of individual ascitic fluids on bacterial growth and ceftriaxone effect in an in vitro model of spontaneous bacterial peritonitis

Nicole

Zimmermann

Integrated in vitro approach to understand the exposure-effect relationship of fosfomycin against Escherichia coli

Amaury

O'Jeanson

A model-based analysis of pharmacokinetic-pharmacodynamic (PK/PD) indices of avibactam against β-lactamase-producing Gram-negative bacteria

Jinxin

Zhao

PhageGE: An Interactive Web-based R Shiny Application for Bacteriophage Pharmacology

Sue

Nang

Elucidating the pharmacokinetics/ pharmacodynamics of bacteriophage therapy against Pseudomonas aeruginosa using a mouse bacteraemia model

Romain

Aubry

Semi-mechanistic PKPD modelling of ceftazidime/avibactam and colistin combination against five multidrug resistant Klebsiella pneumoniae isolates

Mathilde

Lacroix

In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

Matthias

Gijsen

Model-based TDM of vancomycin: a retrospective comparison with routine TDM-based dosing

Gert-Jan

Wijnant

Pharmacokinetics and PK/PD of temocillin in non-ICU urinary tract infection patients with various stages of renal insufficiency

Tim

Ewoldt

Large variability of unbound active fraction of ceftriaxone in contrast to ciprofloxacin in plasma of critically ill patients

Maria

Sanz Codina

Relationship between pharmacokinetic/pharmacodynamic target attainment and microbiological outcome in critically ill COVID-19 patients with documented Gram-negative superinfections treated with meropenem continuous infusion

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ISAP Young Investigators

 

The audience voted for the best Young Investigator presentations: 

Wisse Van Os (Medical University of Vienna, Austria)

Gert-Jan Wijnant (UCLouvain, Belgium)

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The winner of the Young Investigator session Wisse van Os (3rd from left) and runner-up Gert-Jan Wijnant (3rd from right) together with the Young Investigator session chairs Alina Nussbaumer-Pröll and Vincent Aranzana Climent (right) and Sebastian Wicha (President of ISAP) and Markus Zeitlinger (Chair of EPASG) (left).

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All attendees of the ISAP meeting.

 

 

Annual meeting 2021

 The ISAP 2021 meeting was held as a full day virtual conference in collaboration with EPASG on Friday, November 12 2021 - Saturday November 13 2021 as a online meeting.

Program

Friday November 12 2021
13.00-13.10         Welcome on behalf of EPASG
(CET)                     Markus Zeitlinger
 
13.10-13.15         A Themed Issue in Honour of Professor Hartmut Derendorf in ‘Antibiotics’
(CET)                     Francoise Van Bambeke
 
13.15-15.15          Session I: Tribute to Hartmut Derendorf (Ursula Theuretzbacher, William Couet, Markus
(CET)                      Zeitlinger)
Amparo de la Peña: Hartmut Derendorf: Scientific Impact and Personal Legacy
Teresa Dalla Costa: Microdialysis to investigate antimicrobials tissue penetration: lessons learned!!
Günther Hochhaus: Hartmut Derendorf’s impact beyond antimicrobial pharmacology
Jürgen Bulitta: Hartmut Derendorf’s impact on antimicrobial pharmacology over four decades and beyond
 
15.15-15.30          Coffee break
(CET)                                                      
 
15:30-17.00         Session II: Viral PK/PD (Cornelia Landersdorfer, Lena Friberg, Sebastian Wicha)
(CET)                     
Isabelle Bekeredjian-Ding: Regulatory decision making on COVID-19 vaccines
Ashley Brown: Nucleoside/Nucleotide Antiviral Therapy for the Treatment of COVID-19: It’s What’s on the Inside that Counts
Ryan Vargo: Enhancing Antiviral Drug Development through Translation and Quantitative Pharmacology
17.00-17.15         Coffee break        
(CET)
17.15-18.15         Young Investigator Session Part I (Francoise Van Bambeke, Alina Nussbaumer-Pröll)
(CET)
 
Saturday November 13 2021
8.30-9.40              Young Investigator Session Part II (Sandrine Marchand, Elisabet Nielsen)
(CET)
9.40-10:00           Coffee break        
(CET)
10:00-11.15         Session III: Combination therapy (Alexia Chauzy, Thomas Tängdén)
(CET)                     Cornelia Landersdorfer: PK/PD modelling as a tool to better understand drug-drug interactions in combinations
                             Stephen H. Gillespie: A fresh look on drug combinations in TB
11.15-12.00         Lunch break
(CET)
12.00-13.00         Pro/Con: Translating Preclinical Models to Clinical Outcomes (Jian Li, Zackery Bulman)
 (CET)                     Pro:        Sujata Bhavnani
                              Con:        John Turnidge
13.00-14.00         Pro/Con: To TDM or not to TDM? (Birgit Koch, Iris Minichmayr)
 (CET)                      Pro:        Angela Huttner
                               Con:        Bruce Dalton
14.00-14.15         Presentation of the Young Investigator Awards (Alina Nussbaumer-Pröll, Elisabet Nielsen)
(CET)               
      
Closing on behalf of ISAP
Sebastian Wicha
 

 group 1 2021

group 2 2021

 

 

Young Investigator session awards

As per the ISAP tradition, Young Investigators presented their research in the traditional Young Investigator session. The presentation topics ranged from pre-clinical, mechanistic PK-PD studies up to clinical applications of PK-PD. All research was presented very comprehensively and to the highest scientific standards.

The attendees voted the best three presentations who recieved the Young Investigator Awards 2021:

Winner:

Vincent Aranzana-Climent (Uppsala University, Sweden)

 Runner-ups:

Khalid Iqbal (University of Hamburg, Germany)                              Anselm Jorda (Medical University of Vienna, Austria)

 first winner 2021  second winners 2021

 

Annual meeting 2020

 

The ISAP 2020 meeting was held as a virtual meeting on Friday, September 18th, 12:00pm to 2:00pm (CEST) as an online meeting

Schedule 

11:30 to 12:00pm    Council meeting (closed)
12:00 to 12:30pm   General Meeting: Welcome, ISAP discussion, and New Officers
12:30 to 2:00pm Young Investigator Session

  

ISAP Council and General Meeting

Retirement of Council members

The Council for the term 2018-2020 comprised:

  • Brian Tsuji (President)
  • Sebastian Wicha (President-Elect)
  • Zackery Bulman (Treasurer)
  • Jian Li (Secretary)
  • Council members: Hartmut Derendorf, Lena Friberg, Elizabeth Lakota, Justin Lenhard, Elisabet Nielsen, Roger Nation, Ursula Theuretzbacher, Markus Zeitlinger

In the light of many new nominations, Roger Nation, Hartmut Derendorf, Ursula Theuretzbacher, Elizabeth Lakota and Justin Lenhard retired from Council to provide new members the opPicture 2portunity to serve ISAP. With Ursula, Hartmut, and Roger, three former presidents of ISAP and longstanding ISAP members leave the Council.

Brian thanked all retiring Council members for their outstanding services to ISAP, without whom the society would not be the same as it is today.

All members thanked Brian Tsuji for his amazing work he has done as President and beyond. He provided a collegial leadership to ISAP, was a huge supporter of all Young Investigator activities and organized scientific symposia and strategically liaised new collaborations for ISAP. THANK YOU, Brian!

Election of Council members for the term 2020-2022

  • Sebastian Wicha (President)
  • Jian Li (President Elect)
  • Zack Bulman (Treasurer)
  • Elisabet Nielsen (Secretariat)
  • Iris Minichmayr (Secretariat)
  • Council members: Lena Friberg, Markus Zeitlinger, Brian Tsuji, Jürgen Bulitta, Cornelia Landersdorfer, Alina Nussbaumer-Pröll, Nicholas Smith

It is a great to have so many new members on board to join and shape the future of ISAP!

 

Update on ISAP activities

PKPD Webinar (in collaboration with EPASG) – SAVE THE DATE: November 24 2020 –

In collaboration with EPASG, there will be a webinar on “Modeling SARS-Cov-2 viral dynamics to optimize therapy”, by Dr Jeremie Guedj from INSERM, Paris, France held on November 24 2020 4PM CET. The details to join the meeting will be provided in another newsletter. Welcome!

 

ASCPT Pre-Conference 2020

A pre-conference to the ASCPT meeting titled “Translational and Clinical Pharmacology Advances in Anti-Infective Development” was planned for March 18 2019 in collaboration with ASCPT and SIDP. The ISAP contribution was organized by Hartmut Derendorf. A number of ISAP speakers (Lena Friberg, Corneial Landersdorfer, Sebastian Wicha) were scheduled for contributing presentations to the pre-conference. No follow up meeting is planned at this stage, but instead a call for papers to a special issue on Anti-Infectives has been launched in Clinical Pharmacology & Therapeutics. Read more here, in case you wish to contribute.

Antimicrobial Pharmacology at ISICEM 2020 – scheduled for Autumn 2021

ISAP contributed a clinically-oriented session on “Pharmacology of Antibiotics” to the International Symposium on Intensive Care & Emergency Medicine (ISICEM). Iris Minichmayr and Sebastian Wicha were scheduled to contribute presentations on PKPD relationships of antibiotics and interactive case studies for dose individualization. At this stage, the conference is re-scheduled for March 2021. Read more here, in case you are interested to attend.

Face-to-face Meeting(s) 2021

As you all know, the current situation makes it difficult to predict if we can meet in person next year. Potential candidates for a face-to-face meeting are pre or post ECCMID (Vienna, 9-12 July 2021) or a US-based meeting. We will keep you informed.

Online meetings

We are planning a series of regional online meetings to foster scientific exchange between ISAP members. Stay tuned.

 

Scientific Meeting of ISAP – Young Investigator session

As per the ISAP tradition, also in our virtual meeting, Young Investigators presented their research in the traditional Young Investigator session. The presentation topics ranged from pre-clinical, mechanistic PK-PD studies up to clinical applications of PK-PD. All research was presented very comprehensively and to the highest scientific standards. Congratulations to all Young Investigators!

Presenter Title
Zhi Ying Kho Omics of the tripartite relationships among Acinetobacter baumannii, polymyxin and macrophage
Jinxin Zhao Genome-scale metabolic modelling of multidrug-resistant Acinetobacter baumannii revealed significant metabolic changes during bloodstream infection in mice
Niklas Krömer Adaptive optimal design to support efficient high throughput screening of in vitro pharmacodynamic drug interaction studies
Alina Nussbaumer-Pröll Comparison of dosage strategies of meropenem vs. Escherichia coli and Pseudomonas aeruginosa
Tan Xing Activity of simulated ELF concentrations of inhaled and intravenous tobramycin and polymyxin B against Pseudomonas aeruginosa in an in vitro dynamic biofilm model
Hubert Chjua Antiretroviral and β-lactam Combinations against NDM-Producing Klebsiella pneumoniae: Repurposing Zidovudine as Salvage Therapy 
Anders Thorsted Translational modelling of innate immune response following lipopolysaccharide challenge: from piglets to humans 
Josefine Schulz Feasibility investigations of simultaneous microdialysis of voriconazole and its N-oxide metabolite
Luis Ilia Identification and quantification of microdialysis variability using an integrated in vitro, ex vivo and in silico approach.
Anne-Grete Märtson Caspofungin weight-based dosing 

        

Annual meeting 2019

EPASG-EUCAST-ISAP course

Optimised dosing of antibiotics – understanding PK/PD, clinical breakpoints and therapeutic drug monitoring

A 2 day course on PK/PD of anti-infectives was held as a pre-meeting to ECCMID at April 11 -12 2019 in Rotterdam, The Netherlands. The course was organized in collaboration with EPASG and EUCAST and very well attended.

EPASG course

 

Scientific Meeting of ISAP

Standing on the Shoulder of Giants: A Tribute to Alan Forrest.

This year’s ISAP scientific meeting started with a session remembering Alan Forrest, who passed away in August 2018. Alan was a wonderful friend, mentor, colleague and a true inspiration to our community and beyond. In this open session, a number of ISAP members shared personal and scientific memories of Alan with the attendees.

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Brian Tsuji Roger Nation

 

Young Investigator Session

Immediately following the educational course, a Scientific Meeting was held in association with EPASG. As per the ISAP tradition, the meeting focused on the presentation of the research of Young Investigators. With 12 presentations from Young Investigators, a diverse group of studies in antimicrobial PKPD was discussed by the knowledgeable speakers. The slides of the presentations can be found in the Archive (available after login for ISAP members).

Young Investigator presentations:

Presenter

Title

Vincent Aranzana-Climent

Use of a semi-mechanistic PK-PD model to quantify the combination effect of polymyxin B and minocycline against polymyxin-resistant Acinetobacter baumannii

Xiaoting Hua

Formation and evolution of multi-drug resistance plasmid in Proteus mirabilis

Ahmed M. Fathalla

Polymyxins co-localise with different cellular organelles in human macrophages

Jessica R. Tait

Piperacillin/tazobactam plus tobramycin against a clinical Pseudomonas aeruginosa isolate: optimising combination dosage regimens in a dynamic in vitro infection model

Johanna Seeger

Exploring the exposure-effect relationship of levofloxacin against fluoroquinolone resistant Escherichia coli isolates in a dynamic in vitro infection model

Hajira Bilal

Pharmacodynamics of meropenem - tobramycin combination dosage regimens against clinical hypermutable Pseudomonas aeruginosa at simulated epithelial lining fluid concentrations in a dynamic biofilm model

Shachi Mehta

“PK/PD” type of modelling approach to support time-kill data interpretation of cefoxitin for the treatment of Mycobacterium abscessus 

Alina Nussbaumer-Pröll

Comparison of antimicrobial activity and pathogen mutation prevention of originator and generics of cefepime, linezolid and piperacillin-tazobactam

Khalid Iqbal

Towards target site-specific breakpoints combining microdialysis, time-kill curves and physiologically based pharmacokinetic (PBPK) modelling: A case study with moxifloxacin

Sebastian Franck

Boosting the immune system to enhance amoxicillin activity: Insights provided by semi-mechanistic PK/PD modelling

Jinxin Zhao

Battle to the end: uncover the interplay among the host, pathogen and polymyxin in a murine Acinetobacter baumannii bacteremia model by the dual transcriptome analysis

Dinh H. Vu

Determination of optimal loading and maintenance doses for continuous infusion of vancomycin in critically ill patients: population pharmacokinetic modelling and simulation

Congratulations to Sebastian Franck (Freie Universität Berlin / University of Hamburg, Germany) who received the newly introduced Alan Forrest Young Investigator Award for the overall best presentation. Congratulations to Shachi Metha (University of Poitiers, France) and Alina Nussbaumer-Pröll (Medical University of Vienna, Austria) for winning the two runner-up awards in this session.

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Markus Zeitlinger (Chair of EPASG), Zackery Bulman and Sebastian Wicha (Chairs of the ISAP Young Investigator Session), Shachi Metha (Young Investigator Award winner), Thomas Tängdén (Treasurer of EPASG), Sebastian Franck (Alan Forrest Young Investigator Award winner), Alina Nussbaumer-Pröll (Young Investigator Award winner) and Brian Tsuji (President of ISAP).

ISAP Friday April 12 2019

All participants of the 2019 ISAP Meeting

Social Reception

The meetings above were followed by a social gathering in the lobby of the conference hotel Blijdorp Rotterdam to discuss latest news on PK-PD and beyond and to meet old and new colleagues and friends.

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Annual meeting 2018

ISAP Council Meeting and General Meeting

Retirement of Council members

The current Council was elected in 2016 and comprises:

  • Roger Nation (President)
  • Brian Tsuji (President Elect and Treasurer)
  • Ursula Theuretzbacher (Immediate Past President)
  • Lena Friberg and Sebastian Wicha (Joint Secretariat)
  • Council members: Hartmut Derendorf, Justin Lenhard, Johan Mouton, Vincent Tam and Markus Zeitlinger
  • Young Investigator Liaison: Justin Lenhard and Sebastian Wicha

In view of the healthy number of people who nominated for the next Council, Johan Mouton and Vincent Tam kindly offered to retire from Council to provide opportunity for others to serve ISAP.

An amazing feat is that Johan has been on Council for 20 years, with a substantial portion of that time serving as a member of the executive. Indeed, Johan was President Elect of ISAP from 2000 to 2002, President from 2002 to 2004 and Immediate Past President from 2004 to 2006. 

Vincent has served on Council for 10 years, with 8 of those years as Treasurer. Both Johan and Vincent have made an enormous contribution not only to ISAP Council but also to the activities of ISAP more generally (e.g. as key contributors to ISAP educational workshops and conference symposia) and to the discipline.

On behalf of all members of ISAP, Roger and other Council members would like to thank Johan and Vincent for their dedicated service and collegiality, and for their kind offer to provide ongoing support to the Councils of the future. Roger would like to take this opportunity to thank all members of ISAP Council for their wonderful support over the last two years. Of special note is Brian who has been an outstanding President Elect; he will be equally outstanding when he takes on the role of President. Brian would like to thank Roger for the work he has done as President. He has provided compelling leadership to ISAP which has expanded membership, organized key educational symposia, liaised strategic collaborations and allowed ISAP to reach new heights of excellence. Roger’s hard work, dedication and passion for ISAP is extremely inspiring to us all.  With most sincere gratitude from all of us to our fearless and amazing leader – Roger Nation!

Election of Council members for the next two years

There was an excellent response to the call for nominations for membership of the next ISAP Council and for the executive officer positions. The composition of the next Council is as follows:

  • Brian Tsuji (President)
  • Sebastian Wicha (President Elect)
  • Roger Nation (Immediate Past President)
  • Jian Li (Secretary)
  • Zack Bulman (Treasurer)
  • Council members: Hartmut Derendorf, Lena Friberg, Elizabeth Lakota, Justin Lenhard, Elisabet Nielsen, Ursula Theuretzbacher and Markus Zeitlinger

It is truly wonderful to have Jian, Zack, Elizabeth and Elisabet join ISAP Council. The membership of the new Council was ratified by the ISAP members who attended the General Meeting in Madrid. The new Council will commence its term in June 2018.

ISAP Honorary Life Membership Recipient: Professor Otto Cars

At the General Meeting in Madrid, Professor Otto Cars was announced as the recipient of Honorary Life Membership of ISAP. In accordance with ISAP Bylaws, appointment to Life Membership was made on the recommendation of Council. Below is a very brief summary of Otto’s outstanding career, including his key role in creating and nurturing ISAP and his contribution to optimizing the use of antimicrobials and preserving their usefulness for generations to come.

  • Otto Cars was a founding member of ISAP
  • Along with Dr William Craig, Otto organized a landmark meeting in Copenhagen in 1989 that led to ISAP being created in 1991 (see black and white photo)
  • Otto was the second President  of ISAP (1994 - 1996) following the term of William Craig as the initial President (1991 - 1994)
  • Otto became a specialist in infectious diseases in the early 1970s
  • He was appointed Head of the Department of ID at Uppsala University Hospital 1991-1999
  • In 2003, Otto became Professor of ID at Uppsala University
  • Otto’s research over the years has focussed on PK and PD of antibiotics, optimal antibiotic dosing regimens, resistance epidemiology and antibiotic policies
  • Otto has published extensively and is highly respected for the quality and the impact of his work
  • He initiated and/or was a driving influence in numerous Swedish, European and international initiatives to preserve the usefulness of antibiotics (e.g. Member of the WHO Strategic and Technical Advisory Group on Antimicrobial Resistance (STAG-AMR); Founding Director of ReAct in 2005, and since 2013 he is now a senior strategic adviser; Expert member on the recently created UN / WHO  Interagency Coordination Group on Antimicrobial Resistance)
  • Otto has been the recipient of numerous awards for his services to medicine and science (e.g. he was awarded the highly prestigious King’s Medal in 2015)

Interactions with other organizations

On behalf of ISAP, Ursula Theuretzbacher and Sebastian Wicha delivered a 1-hour interactive workshop to ca. 300 participants at the 18th International Congress on Infectious Diseases held in Buenos Aires in March. After an introduction into PK/PD concepts and targets, participants were actively involved in an interactive session. On their mobile devices or laptops, they used the TDMx web application as an example of a precision dosing tool to work on several tasks around dose individualization of β-lactam antibiotics. The session was a great success and the diverse audience (mainly physicians, pediatricians, pharmacists, microbiologists) from all parts of the world seemed to be able to follow the instructions and to experience how PK and PD variables influence dosing decisions.
At the ASM Microbe conference in Atlanta USA in June, ISAP is delivering a pre-conference workshop entitled ‘Introduction to Pharmacokinetics-Pharmacodynamics: A Basic Primer’. The workshop is being delivered by Brian Tsuji, Hartmut Derendorf, Elizabeth Lakota, Vincent Tam and Roger Nation. A Young Investigator night out for ISAP in collaboration with ISoP is being planned by Elizabeth Lakota on Friday June 8 in the late evening. More details will be posted on the ISAP website as the date approaches.
Following the ECCMID meeting in Madrid this year, ISAP worked with EPASG to deliver an oral presentation session within the scientific program of the 3rd International Conference on Polymyxins. ISAP is actively engaged in planning a joint initiative with EPASG and EUCAST to hold an educational / scientific meeting as a satellite to the ECCMID meeting to be held in Amsterdam in April 2019. ISAP and EPASG have held highly successful joint meetings in the past, including the day prior to the ECCMID meeting in Vienna last year.
ISAP Council is very eager to join with other organizations in submitting proposals for symposia and educational workshops at major conferences in various parts of the world. A number of possibilities are under active consideration.

Endorsement of Polymyxin Dosing Guidelines

A unique opportunity for ISAP presented itself to endorse the Polymyxin Guidelines which will be published in Pharmacotherapy and will appear as executive summaries in other journals. ISAP will be endorsing the guidelines along with 6 other international organizations. The guidelines have been accepted by Pharmacotherapy and will be published soon.

ISAP finances and membership

The financial situation of ISAP is healthy and the membership is growing. However, it is very important for members to respond to the call for payment of the annual membership fee. ISAP is not a large organization and it is a time-consuming challenge to send reminder emails to members to prompt them to pay their annual membership subscription. In this regard, the cooperation of all members would be greatly appreciated. It would also be helpful if you would assist in recruiting new members from within your institutions and networks of scientific and clinical colleagues.

Scientific Meeting of ISAP

Immediately following the General Meeting in Madrid, a Scientific Meeting was held in association with EPASG. As per the ISAP tradition, the meeting focused on the presentation of the research of Young Investigators. With 13 presentations from Young Investigators, a diverse group of studies in antimicrobial PKPD was discussed by the knowledgeable speakers. Congratulations to Iain Abbott, Astrid Brӧker, and Nicholas Smith for receiving Young Investigator Awards for their excellent presentations.


All participants of the 2018 ISAP Meeting


Justin Lenhard (chair of the Young Investigator session), Roger Nation (President of ISAP), Iain Abbott, Astrid Bröker and Nicholas Smith (Young Investigator Awardees) and Sebastian Wicha (chair of the Young Investigator session).

Social Reception

The meetings above were followed by a social gathering held in collaboration with the 3rd International Conference on Polymyxins, EPASG and the Spanish Infectious Diseases Society. Approximately 100 people attended this function which provided the opportunity for ISAP members to socialize with their colleagues, meet potential new collaborators and enjoy light appetizers and liquid refreshments.


 

Young Scientist Night Out in Madrid

The night prior to the General Meeting young scientists who participate in ISAP were invited to an informal gathering to network and enjoy the nightlife of Madrid. Over 10 attendees met at the Del Diego Cocktail Bar to mingle and make new connections with peers in the field. Considering the success of the event, ISAP will likely host similar functions in conjunction with future meetings.

 

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