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News May 2013

The 1st International Conference on Polymyxins, an opinion-leader conference to present and learn of the latest findings on the polymyxin antibiotics, took place in on 2 - 4 May, 2013 at the Monash University Centre in Prato, Italy. The organizers and most members of the organizing committee are active members of ISAP: Roger Nation, Australia (Chair), Jian Li, Australia (Deputy Chair), Otto Cars, Sweden, William Couet, France, Mike Dudley, USA, Bob Hancock, Canada, Johan Mouton, Netherlands, David Paterson, Australia, Vincent Tam, USA, Ursula Theuretzbacher, Austria, Brian Tsuji, USA, John Turnidge, Australia.

Despite worldwide fast growth of basic and clinically applied knowledge several key issues such as the optimal dosing regimen (loading dose, timing of first maintenance dose and maintenance doses), potential clinic advantage of combination vs monotherapy, management strategies of nephrotoxicity, huge variability of drug exposure, role for therapeutic drug monitoring, wide quality specifications of content, confusing labelling in different countries, in vitro testing challenges, remain. Shortly, the presentations of the Polymyxin Conference will be posted on the ISAP website. Within each symposium key issues have been identified that will be summarised in the Prato Polymyxin Consensus, in which recommendations will be published to guide the clinical use of polymyxins and identify high-priority areas for further research.

Supporters of the Polymyxin Conference: ISAP, The EU funded project AIDA (Preserving old antibiotics for the future), PK/PD Study Group of ESCMID, ESCMID